Journal Toxicol Environ Health B Crit Rev. Metabolism, genotoxicity, and carcinogenicity of comfrey. Mei N, Guo L, Fu PP, Fuscoe JC, Luan Y, Chen T. Penetration of lycopsamine from a comfrey ointment through human epidermis. Jedlinszki N, Balázs B, Csányi E, Csupor D. The external use of comfrey: a practitioner survey. View abstract.įrost R, O'meara S, Macpherson H. A critical scoping review of external uses of comfrey (Symphytum spp.). Some of these medicines include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.įrost R, Macpherson H, O'meara S. Medications that cause the liver to break down comfrey might increase the toxic effects of chemicals contained in comfrey. Some chemicals that form when the liver breaks down comfrey can be harmful. Medications that increase break down of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers) interacts with COMFREYĬomfrey is broken down by the liver. Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others. Do not take comfrey if you are taking a medication that can harm the liver. Taking comfrey along with medication that might also harm the liver can increase the risk of liver damage. Medications that can harm the liver (Hepatotoxic drugs) interacts with COMFREYĬomfrey might harm the liver.Don't use comfrey if you have any problems with your liver. Liver disease: There is a concern that comfrey might make liver disease worse. Doing so might expose you to large amounts of the chemicals in comfrey that can cause liver damage and other serious health effects. Even topical use is unwise, since the PAs can be absorbed through the skin.īroken or damaged skin: Don't apply comfrey to broken or damaged skin. In addition to causing liver damage and possibly cancer, the PAs in comfrey might also cause birth defects. Pregnancy and breast-feeding: Comfrey is LIKELY UNSAFE to take by mouth or apply to the skin if you are pregnant or breast-feeding. For this reason, it is POSSIBLY UNSAFE to apply comfrey to broken skin or to apply large amounts to the skin for more than 6 weeks. It's important to remember that the poisonous chemicals in comfrey can pass through the skin. When applied to the skin: When applied to unbroken skin in small amounts for less than 10 days, comfrey is POSSIBLY SAFE for most people. The FDA has recommended that all oral comfrey products be removed from the market. It contains chemicals (pyrrolizidine alkaloids, PAs) that can cause liver damage, lung damage, and cancer. When taken by mouth: Comfrey is LIKELY UNSAFE for anyone when taken by mouth.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |